What Are The Best Drugs To Treat Depression?

antidepressantsDepression is a mental health disorder that affects the brain. A lot of people feel depressed when they are struggling in life, lost a loved one, or have a low self-esteem – this is completely normal.

But sometimes, some people can feel an intense sadness that can leave them feeling worthless, hopeless and helpless. Unfortunately, these feelings can last for days to weeks to months or even for years. The depression takes over the state of mind and can keep you from functioning normally in your everyday life. Sometimes this depression can lead to something more than just sadness which may very well be clinical depression that can be treated with medication.

If you are wondering if you might be clinically depressed, you should go talk to a doctor to get diagnosed properly. Usually people with depression have a few of these feelings below, but again, it’s important to talk to your doctor before jumping to any conclusions:

  • Fatigue
  • Insomnia
  • Weight loss
  • Weight gain
  • Depressed mood during most of the day
  • A sense of worthlessness and guilt
  • A sense of restlessness or being slowed down
  • Diminished interest in activities that used to bring pleasure
  • Hypersomnia (excessive sleeping)
  • Lack of concentration
  • Indecisiveness




  • Tricyclic antidepressants: This can be very effective, but can also tend to cause very severe side-effects. They are not generally prescribed unless others you have tried do not work. These include Tofranil, Pamelor, Surmontil, Norpramin, and Vivactil.
  • Monoamine oxidase inhibitors: This can be prescribed, but when all other medications have not worked because they also have serious side-effects as well. It also requires a very strict diet. These include Parnate, Nardil, Marplan, and Emsam.
  • Selective serotonin reuptake inhibitors: Doctors often prescribe this medication because they have fewer side effects than other anti-depressions. Some of these include Prozac, Paxil, Pexeva, Zoloft, Citalopram, Celexa, Escitalopram, and Lexapro.
  • Serotonin-norepinephrine reuptake inhibitors: Examples of this drug include Cymbaita, Effexor XR, Pristiq, Khedezla, Fetzima.
  • Norepinephrine-dopamine reuptake inhibitors: Bupropion falls into this category as well. It’s one of the few drugs not frequently associated with sexual side effects.
  • Atypical antidepressants: Trazodone, Remeron, Brintellix, Viibryd, and Vilazadone all fall into this category. This isn’t commonly used because of possible sexual side effects.


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Sometimes your doctor will prescribe you with different kinds over a period of time to see which medication will be the right one for you. They will also check into your family history to see if maybe one of your family members with depression responded well to an antidepressant because it may also work for you. It requires a lot of patience to find the right one because sometimes medications can take up to weeks to finally take full effect in your body and also help your body adjust to the side effects.

Also, your doctor may also do some genetic testing to offer clues about how your body may respond to a particular antidepressant, but it’s important to note that other variables besides genetics can affect your response to medication.